Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-Mutant Colorectal Cancer Models

PURPOSE: Despite the availability of several active combination regimens for advanced colorectal cancer (CRC), the 5-year survival rate remains poor at less than 10%,supporting the development of novel therapeutic approaches. In this study, we focused on the preclinical assessment of a rationally ba...

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Detalhes bibliográficos
Main Authors: Morelli, M. Pia, Tentler, John J., Kulikowski, Gillian N., Tan, Aik-Choon, Bradshaw-Pierce, Erica L., Pitts, Todd M., Brown, Amy M., Nallapareddy, Sujatha, Arcaroli, John J., Serkova, Natalie J., Hidalgo, Manuel, Ciardiello, Fortunato, Eckhardt, S. Gail
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876277/
https://ncbi.nlm.nih.gov/pubmed/22173548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1507
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