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Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines

BACKGROUND: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of...

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Bibliografiske detaljer
Main Authors: Terheggen, Ulrich, Drew, Damien R, Hodder, Anthony N, Cross, Nadia J, Mugyenyi, Cleopatra K, Barry, Alyssa E, Anders, Robin F, Dutta, Sheetij, Osier, Faith HA, Elliott, Salenna R, Senn, Nicolas, Stanisic, Danielle I, Marsh, Kevin, Siba, Peter M, Mueller, Ivo, Richards, Jack S, Beeson, James G
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212128/
https://ncbi.nlm.nih.gov/pubmed/25319190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-014-0183-5
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