Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens

BACKGROUND: Malaria is a major global cause of deaths and a vaccine is urgently needed. RESULTS: We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled them in different ways using surface plasmon resonance (SPR) and estimated affinity (measured...

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Udgivet i:BMC Microbiol
Main Authors: Reddy, Sreenivasulu B., Anders, Robin F., Cross, Nadia, Mueller, Ivo, Senn, Nicolas, Stanisic, Danielle I., Siba, Peter M., Wahlgren, Mats, Kironde, Fred, Beeson, James G., Persson, Kristina E.M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491891/
https://ncbi.nlm.nih.gov/pubmed/26149471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12866-015-0461-1
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