Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines

BACKGROUND: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of...

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Main Authors: Terheggen, Ulrich, Drew, Damien R, Hodder, Anthony N, Cross, Nadia J, Mugyenyi, Cleopatra K, Barry, Alyssa E, Anders, Robin F, Dutta, Sheetij, Osier, Faith HA, Elliott, Salenna R, Senn, Nicolas, Stanisic, Danielle I, Marsh, Kevin, Siba, Peter M, Mueller, Ivo, Richards, Jack S, Beeson, James G
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212128/
https://ncbi.nlm.nih.gov/pubmed/25319190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-014-0183-5
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