Adoptive Transfer of Heme Oxygenase-1 (HO-1)–Modified Macrophages Rescues the Nuclear Factor Erythroid 2–Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury

Macrophages are instrumental in the pathophysiology of liver ischemia/reperfusion injury (IRI). Although Nrf2 regulates macrophage-specific heme oxygenase-1 (HO-1) antioxidant defense, it remains unknown whether HO-1 induction might rescue macrophage Nrf2-dependent antiinflammatory functions. This s...

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Bibliografiske detaljer
Main Authors: Huang, Jing, Shen, Xiu-Da, Yue, Shi, Zhu, Jianjun, Gao, Feng, Zhai, Yuan, Busuttil, Ronald W, Ke, Bibo, Kupiec-Weglinski, Jerzy W
Format: Artigo
Sprog:Inglês
Udgivet: ScholarOne 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212016/
https://ncbi.nlm.nih.gov/pubmed/25014792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2014.00103
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