Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance

[Image: see text] In Huntington’s disease, expansion of a polyglutamine (polyQ) domain in the huntingtin (htt) protein leads to misfolding and aggregation. There is much interest in the molecular features that distinguish monomeric, oligomeric, and fibrillar species that populate the aggregation pat...

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Bibliografiske detaljer
Main Authors: Hoop, Cody L., Lin, Hsiang-Kai, Kar, Karunakar, Hou, Zhipeng, Poirier, Michelle A., Wetzel, Ronald, van der Wel, Patrick C. A.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211650/
https://ncbi.nlm.nih.gov/pubmed/25280367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501010q
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