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Intrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors

Control over the sensitivity with which biomolecular receptors respond to small changes in the concentration of their target ligand is critical for the proper function of many cellular processes. Such control could likewise be of utility in artificial biotechnologies, such as biosensors, genetic log...

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Hlavní autoři: Simon, Anna J., Vallée-Bélisle, Alexis, Ricci, Francesco, Plaxco, Kevin W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210277/
https://ncbi.nlm.nih.gov/pubmed/25288724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410796111
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