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Using the population-shift mechanism to rationally introduce “Hill-type” cooperativity into a normally non-cooperative receptor
Allosteric cooperativity, which nature uses to improve the sensitivity with which biomolecular receptors respond to small changes in ligand concentration, could likewise be of use in improving the responsiveness of artificial biosystems. Thus motivated, we demonstrate here the rational design of coo...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5660314/ https://ncbi.nlm.nih.gov/pubmed/25044647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201403777 |
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