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Computational Study of Gleevec and G6G Reveals Molecular Determinants of Kinase Inhibitor Selectivity
[Image: see text] Gleevec is a potent inhibitor of Abl tyrosine kinase but not of the highly homologous c-Src kinase. Because the ligand binds to an inactive form of the protein in which an Asp-Phe-Gly structural motif along the activation loop adopts a so-called DFG-out conformation, it was suggest...
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| Главные авторы: | , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical
Society
2014
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210138/ https://ncbi.nlm.nih.gov/pubmed/25243930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja504146x |
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