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Explaining why Gleevec is a specific and potent inhibitor of Abl kinase
Tyrosine kinases present attractive drug targets for specific types of cancers. Gleevec, a well-known therapeutic agent against chronic myelogenous leukemia, is an effective inhibitor of Abl tyrosine kinase. However, Gleevec fails to inhibit closely homologous tyrosine kinases, such as c-Src. Becaus...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3562763/ https://ncbi.nlm.nih.gov/pubmed/23319661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214330110 |
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