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Single-molecule investigation of G-quadruplex folds of the human telomere sequence in a protein nanocavity
Human telomeric DNA consists of tandem repeats of the sequence 5′-TTAGGG-3′ that can fold into various G-quadruplexes, including the hybrid, basket, and propeller folds. In this report, we demonstrate use of the α-hemolysin ion channel to analyze these subtle topological changes at a nanometer scale...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4209999/ https://ncbi.nlm.nih.gov/pubmed/25225404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415944111 |
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