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Interactions of the human telomere sequence with the nanocavity of the α-hemolysin ion channel reveal structure-dependent electrical signatures for hybrid folds

Human telomeric DNA consists of tandem repeats of the sequence 5′-TTAGGG-3′, including a 3′ terminal single-stranded overhang of 100–200 nucleotides that can fold into quadruplex structures in the presence of suitable metal ions. In the presence of an applied voltage, the α-hemolysin (α-HL) protein...

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Bibliografiske detaljer
Main Authors: An, Na, Fleming, Aaron M., Burrows, Cynthia J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709467/
https://ncbi.nlm.nih.gov/pubmed/23682802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400973m
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