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Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin
Heparanase activity plays a decisive role in cell dissemination associated with cancer metastasis. Cellular uptake of heparanase is considered a pre-requisite for the delivery of latent 65-kDa heparanase to lysosomes and its subsequent proteolytic processing and activation into 8- and 50-kDa protein...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Basel
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4209210/ https://ncbi.nlm.nih.gov/pubmed/24788042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-014-1629-9 |
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