Vasorelaxant effects of novel K(v)7.4 channel enhancers ML213 and NS15370

BACKGROUND AND PURPOSE: The KCNQ-encoded voltage-gated potassium channel family (K(v)7.1-K(v)7.5) are established regulators of smooth muscle contractility, where K(v)7.4 and K(v)7.5 predominate. Various K(v)7.2–7.5 channel enhancers have been developed that have been shown to cause a vasorelaxation...

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Detalhes bibliográficos
Main Authors: Jepps, T A, Bentzen, B H, Stott, J B, Povstyan, O V, Sivaloganathan, K, Dalby-Brown, W, Greenwood, I A
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209148/
https://ncbi.nlm.nih.gov/pubmed/24909207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12805
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