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Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

Novel allosteric modulators of G protein-coupled receptors (GPCRs) are providing fundamental advances in the development of GPCR ligands with high subtype selectivity and novel modes of efficacy that have not been possible with traditional approaches. As new allosteric modulators are advancing as dr...

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Main Authors: Conn, P. Jeffrey, Lindsley, Craig W., Meiler, Jens, Niswender, Colleen M.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208620/
https://ncbi.nlm.nih.gov/pubmed/25176435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd4308
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