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Computational and Biochemical Docking of the Irreversible Cocaine Analog RTI 82 Directly Demonstrates Ligand Positioning in the Dopamine Transporter Central Substrate-binding Site

The dopamine transporter (DAT) functions as a key regulator of dopaminergic neurotransmission via re-uptake of synaptic dopamine (DA). Cocaine binding to DAT blocks this activity and elevates extracellular DA, leading to psychomotor stimulation and addiction, but the mechanisms by which cocaine inte...

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Detalhes bibliográficos
Main Authors: Dahal, Rejwi Acharya, Pramod, Akula Bala, Sharma, Babita, Krout, Danielle, Foster, James D., Cha, Joo Hwan, Cao, Jianjing, Newman, Amy Hauck, Lever, John R., Vaughan, Roxanne A., Henry, L. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207985/
https://ncbi.nlm.nih.gov/pubmed/25179220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571521
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