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Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113

Cocaine binds and inhibits dopamine transporter (DAT), norepinephrine transporter (NET) and serotonin transporter. The residues forming cocaine binding sites are unknown. RTI-113, a cocaine analog, is 100x more potent at inhibiting DAT than inhibiting NET. Here we show that removing the hydroxyl gro...

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Detalhes bibliográficos
Main Authors: Hill, Erik R., Huang, Xiaoqin, Zhan, Chang-Guo, Carroll, F. Ivy, Gu, Howard H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105219/
https://ncbi.nlm.nih.gov/pubmed/21420984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2011.03.014
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