Computational and Biochemical Docking of the Irreversible Cocaine Analog RTI 82 Directly Demonstrates Ligand Positioning in the Dopamine Transporter Central Substrate-binding Site

The dopamine transporter (DAT) functions as a key regulator of dopaminergic neurotransmission via re-uptake of synaptic dopamine (DA). Cocaine binding to DAT blocks this activity and elevates extracellular DA, leading to psychomotor stimulation and addiction, but the mechanisms by which cocaine inte...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Dahal, Rejwi Acharya, Pramod, Akula Bala, Sharma, Babita, Krout, Danielle, Foster, James D., Cha, Joo Hwan, Cao, Jianjing, Newman, Amy Hauck, Lever, John R., Vaughan, Roxanne A., Henry, L. Keith
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2014
主題:
Membrane Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207985/
https://ncbi.nlm.nih.gov/pubmed/25179220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571521
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍