A 3′-UTR KRAS-variant is associated with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma

BACKGROUND: A germline mutation in the 3′-untranslated region of KRAS (rs61764370, KRAS-variant: TG/GG) has previously been associated with altered patient outcome and drug resistance/sensitivity in various cancers. We examined the prognostic and predictive significance of this variant in recurrent/...

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Main Authors: Chung, C. H., Lee, J. W., Slebos, R. J., Howard, J. D., Perez, J., Kang, H., Fertig, E. J., Considine, M., Gilbert, J., Murphy, B. A., Nallur, S., Paranjape, T., Jordan, R. C., Garcia, J., Burtness, B., Forastiere, A. A., Weidhaas, J. B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207729/
https://ncbi.nlm.nih.gov/pubmed/25081901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdu367
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