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Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach

Novel anthracenone derivatives were designed through in silico studies including 3D QSAR, pharmacophore mapping, and molecular docking approaches. Tubulin protein was explored for the residues imperative for activity by analyzing the binding pattern of colchicine and selected compounds of anthraceno...

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Autors principals: Samad, Abdul, Naffaa, Moawiah M., Bakht, Mohammed Afroz, Malhotra, Manav, Ganaie, Majid A.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207406/
https://ncbi.nlm.nih.gov/pubmed/25383219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/658016
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