Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach

Novel anthracenone derivatives were designed through in silico studies including 3D QSAR, pharmacophore mapping, and molecular docking approaches. Tubulin protein was explored for the residues imperative for activity by analyzing the binding pattern of colchicine and selected compounds of anthraceno...

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Detalhes bibliográficos
Main Authors: Samad, Abdul, Naffaa, Moawiah M., Bakht, Mohammed Afroz, Malhotra, Manav, Ganaie, Majid A.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207406/
https://ncbi.nlm.nih.gov/pubmed/25383219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/658016
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