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Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors

New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace the central ring in colchicine. Different functional groups (R(1)) were attached to manipulate their physicochemical properties and/or their...

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書目詳細資料
發表在:J Enzyme Inhib Med Chem
Main Authors: Ahmed, Riham I., Osman, Essam Eldin A., Awadallah, Fadi M., El-Moghazy, Samir M.
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009925/
https://ncbi.nlm.nih.gov/pubmed/27771966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1244532
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