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Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors

New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace the central ring in colchicine. Different functional groups (R(1)) were attached to manipulate their physicochemical properties and/or their...

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Bibliographische Detailangaben
Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Ahmed, Riham I., Osman, Essam Eldin A., Awadallah, Fadi M., El-Moghazy, Samir M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009925/
https://ncbi.nlm.nih.gov/pubmed/27771966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1244532
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