Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors

New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace the central ring in colchicine. Different functional groups (R(1)) were attached to manipulate their physicochemical properties and/or their...

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Vydáno v:J Enzyme Inhib Med Chem
Hlavní autoři: Ahmed, Riham I., Osman, Essam Eldin A., Awadallah, Fadi M., El-Moghazy, Samir M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009925/
https://ncbi.nlm.nih.gov/pubmed/27771966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1244532
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