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Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors

New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace the central ring in colchicine. Different functional groups (R(1)) were attached to manipulate their physicochemical properties and/or their...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Enzyme Inhib Med Chem
Päätekijät: Ahmed, Riham I., Osman, Essam Eldin A., Awadallah, Fadi M., El-Moghazy, Samir M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009925/
https://ncbi.nlm.nih.gov/pubmed/27771966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1244532
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