Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis

Intestinal fibrostenosis is among the hallmarks of severe Crohn’s disease. Patients with certain TNFSF15 (gene name for TL1A) variants over-express TL1A and have a higher risk of developing strictures in the small intestine. Additionally, sustained Tl1a expression in mice leads to small and large in...

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Detalhes bibliográficos
Main Authors: Shih, David Q, Zheng, Libo, Zhang, Xiaolan, Zhang, Hong, Kanazawa, Yoshitake, Ichikawa, Ryan, Wallace, Kori L, Chen, Jeremy, Pothoulakis, Charalabos, Koon, Hon W, Targan, Stephan R
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205266/
https://ncbi.nlm.nih.gov/pubmed/24850426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.37
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