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Poliovirus tropism and attenuation are determined after internal ribosome entry
Poliovirus replication is limited to a few organs, including the brain and spinal cord. This restricted tropism may be a consequence of organ-specific differences in translation initiation by the poliovirus internal ribosome entry site (IRES). A C-to-U mutation at base 472 in the IRES of the Sabin t...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC420511/ https://ncbi.nlm.nih.gov/pubmed/15199409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421323 |
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