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Poliovirus tropism and attenuation are determined after internal ribosome entry

Poliovirus replication is limited to a few organs, including the brain and spinal cord. This restricted tropism may be a consequence of organ-specific differences in translation initiation by the poliovirus internal ribosome entry site (IRES). A C-to-U mutation at base 472 in the IRES of the Sabin t...

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Sonraí Bibleagrafaíochta
Main Authors: Kauder, Steven E., Racaniello, Vincent R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC420511/
https://ncbi.nlm.nih.gov/pubmed/15199409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421323
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