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The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus
Little is known about the mutational fitness effects associated with single-nucleotide substitutions on RNA viral genomes. Here, we used site-directed mutagenesis to create 91 single mutant clones of vesicular stomatitis virus derived from a common ancestral cDNA and performed competition experiment...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2004
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC420405/ https://ncbi.nlm.nih.gov/pubmed/15159545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400146101 |
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