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Evidence for assembly of prions with left-handed β-helices into trimers

Studies using low-resolution fiber diffraction, electron microscopy, and atomic force microscopy on various amyloid fibrils indicate that the misfolded conformers must be modular, compact, and adopt a cross-β structure. In an earlier study, we used electron crystallography to delineate molecular mod...

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Autors principals: Govaerts, Cédric, Wille, Holger, Prusiner, Stanley B., Cohen, Fred E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC420396/
https://ncbi.nlm.nih.gov/pubmed/15155909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402254101
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