Apaf-1 Inhibitors Protect from Unwanted Cell Death in In Vivo Models of Kidney Ischemia and Chemotherapy Induced Ototoxicity

BACKGROUND: Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although such inhibitors were effective, safety problems led to slow pharmacological d...

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Main Authors: Orzáez, Mar, Sancho, Mónica, Marchán, Sandra, Mondragón, Laura, Montava, Rebeca, Valero, Juan García, Landeta, Olatz, Basañez, Gorka, Carbajo, Rodrigo J., Pineda-Lucena, Antonio, Bujons, Jordi, Moure, Alejandra, Messeguer, Angel, Lagunas, Carmen, Herrero, Carmen, Pérez-Payá, Enrique
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203855/
https://ncbi.nlm.nih.gov/pubmed/25330150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110979
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