Synthesis and Incorporation of the Phosphoramidite Derivative of 2′-O-Photocaged 3′-S-Thioguanosine into Oligoribonucleotides: Substrate for Probing the Mechanism of RNA Catalysis

[Image: see text] Oligoribonucleotides containing 3′-S-phosphorothiolate linkages possess properties that can reveal deep mechanistic insights into ribozyme-catalyzed reactions. “Photocaged” 3′-S- RNAs could provide a strategy to stall reactions at the chemical stage and release them after assembly...

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Bibliographic Details
Main Authors: Li, Nan-Sheng, Tuttle, Nicole, Staley, Jonathan P., Piccirilli, Joseph A.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203407/
https://ncbi.nlm.nih.gov/pubmed/24635216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo4028374
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