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Synthesis of 5´-Thio-3´-O-Ribonucleoside Phosphoramidites

The chemical synthesis of phosphoramidite derivatives of all four 5´-deoxy-5´-thioribonucleosides is described. These phosphoramidites contained either trityl (A, G, C and U), dimethoxytrityl (A, G) or tert-butyldisulfanyl (G) as the 5´-S protecting group. The application of several of these phospho...

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Publicado en:J Org Chem
Autores principales: Li, Nan-Sheng, Lu, Jun, Piccirilli, Joseph A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557410/
https://ncbi.nlm.nih.gov/pubmed/29049877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b01484
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