Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity

The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K). Approximately 70% of ODGs with 1p19q co-deletions harbor somatic mutations in the Capicua Transcriptional Repressor (CIC) gene on chromoso...

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Autori principali: Chittaranjan, Suganthi, Chan, Susanna, Yang, Cindy, Yang, Kevin C., Chen, Vincent, Moradian, Annie, Firme, Marlo, Song, Jungeun, Go, Nancy E., Blough, Michael D., Chan, Jennifer A., Cairncross, J. Gregory, Gorski, Sharon M., Morin, Gregg B., Yip, Stephen, Marra, Marco A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4202173/
https://ncbi.nlm.nih.gov/pubmed/25277207
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