Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas

The intrinsic signaling cascades and cell states associated with the Glioma CpG Island Methylator Phenotype (G-CIMP) remain poorly understood. Using published mRNA signatures associated with EGFR activation, we demonstrate that G-CIMP+ tumors harbor decreased EGFR signaling using three independent d...

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Detalhes bibliográficos
Main Authors: Li, Jie, Taich, Zachary J., Goyal, Amit, Gonda, David, Akers, Johnny, Adhikari, Bandita, Patel, Kunal, Vandenberg, Scott, Yan, Wei, Bao, Zhaoshi, Carter, Bob S., Wang, Renzhi, Mao, Ying, Jiang, Tao, Chen, Clark C.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4202127/
https://ncbi.nlm.nih.gov/pubmed/25277177
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