Molecular Mechanism of Constitutive Endocytosis of Acid-Sensing Ion Channel 1a and Its Protective Function in Acidosis-Induced Neuronal Death

Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the peripheral and CNSs, which critically contribute to a variety of pathophysiological conditions that involve tissue acidosis, such as ischemic stroke and epileptic seizures. However, the trafficking mechanisms...

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Main Authors: Zeng, Wei-Zheng, Liu, Di-Shi, Duan, Bo, Song, Xing-Lei, Wang, Xiang, Wei, Dong, Jiang, Wen, Zhu, Michael X., Li, Yong, Xu, Tian-Le
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201763/
https://ncbi.nlm.nih.gov/pubmed/23595764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5206-12.2013
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