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Dynorphin Opioid Peptides Enhance Acid-Sensing Ion Channel 1a Activity and Acidosis-Induced Neuronal Death

Acid-sensing ion channel 1a (ASIC1a) promotes neuronal damage during pathological acidosis. ASIC1a undergoes a process called steady-state desensitization in which incremental pH reductions desensitize the channel and prevent activation when the threshold for acid-dependent activation is reached. We...

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Autori principali: Sherwood, Thomas W., Askwith, Candice C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802056/
https://ncbi.nlm.nih.gov/pubmed/19906984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2186-09.2009
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