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A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas
Pediatric glioblastomas (GBM) are highly aggressive and lethal tumors. Recent sequencing studies have shown that ~30 % of pediatric GBM and ~80 % of diffuse intrinsic pontine gliomas show K27M mutations in the H3F3A gene, a variant encoding histone H3.3. H3F3A K27M mutations lead to global reduction...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Springer Berlin Heidelberg
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4201755/ https://ncbi.nlm.nih.gov/pubmed/25200322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1338-3 |
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