A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas

Pediatric glioblastomas (GBM) are highly aggressive and lethal tumors. Recent sequencing studies have shown that ~30 % of pediatric GBM and ~80 % of diffuse intrinsic pontine gliomas show K27M mutations in the H3F3A gene, a variant encoding histone H3.3. H3F3A K27M mutations lead to global reduction...

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Autors principals: Venneti, Sriram, Santi, Mariarita, Felicella, Michelle Madden, Yarilin, Dmitry, Phillips, Joanna J., Sullivan, Lisa M., Martinez, Daniel, Perry, Arie, Lewis, Peter W., Thompson, Craig B., Judkins, Alexander R.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2014
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201755/
https://ncbi.nlm.nih.gov/pubmed/25200322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1338-3
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