Histone 3 Lysine 9 Trimethylation Is Differentially Associated with Isocitrate Dehydrogenase Mutations in Oligodendrogliomas and High-Grade Astrocytomas

Trimethylation of histone 3 lysine 9 (H3K9me3) is a marker of repressed transcription. Cells transfected with mutant isocitrate dehydrogenase (IDH) show increased methylation of histone lysine residues, including H3K9me3, due to inhibition of histone demethylases by 2-hydroxyglutarate. Here, we eval...

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Hauptverfasser: Venneti, Sriram, Felicella, Michelle Madden, Coyne, Thomas, Phillips, Joanna J., Gorovets, Daniel, Huse, Jason T., Kofler, Julia, Lu, Chao, Tihan, Tarik, Sullivan, Lisa M., Santi, Mariarita, Judkins, Alexander R., Perry, Arie, Thompson, Craig B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615673/
https://ncbi.nlm.nih.gov/pubmed/23481705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3182898113
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