Histone 3 Lysine 9 Trimethylation Is Differentially Associated with Isocitrate Dehydrogenase Mutations in Oligodendrogliomas and High-Grade Astrocytomas

Trimethylation of histone 3 lysine 9 (H3K9me3) is a marker of repressed transcription. Cells transfected with mutant isocitrate dehydrogenase (IDH) show increased methylation of histone lysine residues, including H3K9me3, due to inhibition of histone demethylases by 2-hydroxyglutarate. Here, we eval...

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書誌詳細
主要な著者: Venneti, Sriram, Felicella, Michelle Madden, Coyne, Thomas, Phillips, Joanna J., Gorovets, Daniel, Huse, Jason T., Kofler, Julia, Lu, Chao, Tihan, Tarik, Sullivan, Lisa M., Santi, Mariarita, Judkins, Alexander R., Perry, Arie, Thompson, Craig B.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615673/
https://ncbi.nlm.nih.gov/pubmed/23481705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3182898113
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