Histone 3 Lysine 9 Trimethylation Is Differentially Associated with Isocitrate Dehydrogenase Mutations in Oligodendrogliomas and High-Grade Astrocytomas

Trimethylation of histone 3 lysine 9 (H3K9me3) is a marker of repressed transcription. Cells transfected with mutant isocitrate dehydrogenase (IDH) show increased methylation of histone lysine residues, including H3K9me3, due to inhibition of histone demethylases by 2-hydroxyglutarate. Here, we eval...

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Autori principali: Venneti, Sriram, Felicella, Michelle Madden, Coyne, Thomas, Phillips, Joanna J., Gorovets, Daniel, Huse, Jason T., Kofler, Julia, Lu, Chao, Tihan, Tarik, Sullivan, Lisa M., Santi, Mariarita, Judkins, Alexander R., Perry, Arie, Thompson, Craig B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615673/
https://ncbi.nlm.nih.gov/pubmed/23481705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3182898113
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