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The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins
A baffling aspect of metazoan proteostasis is the lack of an Hsp104 ortholog that rapidly disaggregates and reactivates misfolded polypeptides trapped in stress induced disordered aggregates, preamyloid oligomers, or amyloid fibrils. By contrast, in bacteria, protozoa, chromista, fungi, and plants,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4201613/ https://ncbi.nlm.nih.gov/pubmed/24401655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.27531 |
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