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The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System
Bacteria, fungi, protozoa, chromista and plants all harbor homologues of Hsp104, a AAA+ ATPase that collaborates with Hsp70 and Hsp40 to promote protein disaggregation and reactivation. Curiously, however, metazoa do not possess an Hsp104 homologue. Thus, whether animal cells renature large protein...
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| Natura: | Artigo |
| Lingua: | Inglês |
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Public Library of Science
2011
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3194798/ https://ncbi.nlm.nih.gov/pubmed/22022600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026319 |
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