Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation, and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoural heterogeneity of medulloblastoma, identif...

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Main Authors: Northcott, Paul A, Lee, Catherine, Zichner, Thomas, Stütz, Adrian M, Erkek, Serap, Kawauchi, Daisuke, Shih, David JH, Hovestadt, Volker, Zapatka, Marc, Sturm, Dominik, Jones, David TW, Kool, Marcel, Remke, Marc, Cavalli, Florence, Zuyderduyn, Scott, Bader, Gary, VandenBerg, Scott, Esparza, Lourdes Adriana, Ryzhova, Marina, Wang, Wei, Wittmann, Andrea, Stark, Sebastian, Sieber, Laura, Seker-Cin, Huriye, Linke, Linda, Kratochwil, Fabian, Jäger, Natalie, Buchhalter, Ivo, Imbusch, Charles D, Zipprich, Gideon, Raeder, Benjamin, Schmidt, Sabine, Diessl, Nicolle, Wolf, Stephan, Wiemann, Stefan, Brors, Benedikt, Lawerenz, Chris, Eils, Jürgen, Warnatz, Hans-Jörg, Risch, Thomas, Yaspo, Marie-Laure, Weber, Ursula D, Bartholomae, Cynthia C, von Kalle, Christof, Turányi, Eszter, Hauser, Peter, Sanden, Emma, Darabi, Anna, Siesjö, Peter, Sterba, Jaroslav, Zitterbart, Karel, Sumerauer, David, van Sluis, Peter, Versteeg, Rogier, Volckmann, Richard, Koster, Jan, Schuhmann, Martin U, Ebinger, Martin, Grimes, H. Leighton, Robinson, Giles W, Gajjar, Amar, Mynarek, Martin, von Hoff, Katja, Rutkowski, Stefan, Pietsch, Torsten, Scheurlen, Wolfram, Felsberg, Jörg, Reifenberger, Guido, Kulozik, Andreas E, von Deimlmg, Andreas, Witt, Olaf, Eils, Roland, Gilbertson, Richard J, Korshunov, Andrey, Taylor, Michael D, Lichter, Peter, Korbel, Jan O, Wechsler-Reya, Robert J, Pfister, Stefan M
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201514/
https://ncbi.nlm.nih.gov/pubmed/25043047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13379
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