Redesigning Human 2′-Deoxycytidine Kinase Enantioselectivity for l-Nucleoside Analogues as Reporters in Positron Emission Tomography

[Image: see text] Recent advances in nuclear medicine have allowed for positron emission tomography (PET) to track transgenes in cell-based therapies using PET reporter gene/probe pairs. A promising example for such reporter gene/probe pairs are engineered nucleoside kinases that effectively phospho...

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Bibliographic Details
Main Authors: Muthu, Pravin, Chen, Hannah X., Lutz, Stefan
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201336/
https://ncbi.nlm.nih.gov/pubmed/25079348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500463f
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