Development of new deoxycytidine kinase inhibitors and non-invasive in vivo evaluation using Positron Emission Tomography

Combined inhibition of ribonucleotide reductase and deoxycytidine kinase (dCK) in multiple cancer cell lines depletes deoxycytidine triphosphate pools leading to DNA replication stress, cell cycle arrest and apoptosis. Evidence implicating dCK in cancer cell proliferation and survival stimulated our...

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Hlavní autoři: Murphy, Jennifer M., Armijo, Amanda L., Nomme, Julian, Lee, Chi Hang, Smith, Quentin A., Li, Zheng, Campbell, Dean O., Liao, Hsiang-I, Nathanson, David A., Austin, Wayne R., Lee, Jason T., Darvish, Ryan, Wei, Liu, Wang, Jue, Su, Ying, Damoiseaux, Robert, Sadeghi, Saman, Phelps, Michael E., Herschman, Harvey R., Czernin, Johannes, Alexandrova, Anastassia N., Jung, Michael E., Lavie, Arnon, Radu, Caius G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789385/
https://ncbi.nlm.nih.gov/pubmed/23947754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400457y
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