Role of Tyrosine Kinase Inhibitors in the Management of Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

The Philadelphia chromosome is the most common cytogenetic abnormality found in adult patients diagnosed with acute lymphoblastic leukemia. The result of this abnormality is the BCR-ABL protein, a constitutively active kinase involved in cell signaling and survival. When managed with multiagent chem...

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Bibliographic Details
Main Authors: Mathisen, Michael S., O’Brien, Susan, Thomas, Deborah, Cortes, Jorge, Kantarjian, Hagop, Ravandi, Farhad
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201047/
https://ncbi.nlm.nih.gov/pubmed/21660654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11899-011-0093-y
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