Role of Tyrosine Kinase Inhibitors in the Management of Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

The Philadelphia chromosome is the most common cytogenetic abnormality found in adult patients diagnosed with acute lymphoblastic leukemia. The result of this abnormality is the BCR-ABL protein, a constitutively active kinase involved in cell signaling and survival. When managed with multiagent chem...

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Bibliografiska uppgifter
Huvudupphovsmän: Mathisen, Michael S., O’Brien, Susan, Thomas, Deborah, Cortes, Jorge, Kantarjian, Hagop, Ravandi, Farhad
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201047/
https://ncbi.nlm.nih.gov/pubmed/21660654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11899-011-0093-y
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