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O06 TARGETING FOXM1 AS A NOVEL THERAPEUTIC STRATEGY FOR THE TREATMENT OF MSH6 DEFICIENT TEMOZOLOMIDE-RESISTANT GLIOBLASTOMA
INTRODUCTION: Mutations in the DNA mismatch repair gene MSH6 can arise in glioblastoma cells during Temozolomide treatment and can mediate drug resistance. Recently, exploiting the concept of synthetic lethality has been proposed as a therapeutic strategy. METHOD & RESULTS: Based on this approac...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4200949/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou250.6 |
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