O06 TARGETING FOXM1 AS A NOVEL THERAPEUTIC STRATEGY FOR THE TREATMENT OF MSH6 DEFICIENT TEMOZOLOMIDE-RESISTANT GLIOBLASTOMA

INTRODUCTION: Mutations in the DNA mismatch repair gene MSH6 can arise in glioblastoma cells during Temozolomide treatment and can mediate drug resistance. Recently, exploiting the concept of synthetic lethality has been proposed as a therapeutic strategy. METHOD & RESULTS: Based on this approac...

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Main Authors: Brierley, David J., Locke, Matthew, Merve, Ashirwad, Marino, Silvia, Martin, Sarah A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
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Abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200949/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou250.6
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