Translocation of Glycogen Synthase Kinase-3β (GSK-3β), a Trigger of Permeability Transition, Is Kinase Activity-dependent and Mediated by Interaction with Voltage-dependent Anion Channel 2 (VDAC2)

Glycogen synthase kinase-3β (GSK-3β) is a major positive regulator of the mitochondrial permeability transition pore (mPTP), a principle trigger of cell death, under the condition of oxidative stress. However, the mechanism by which cytosolic GSK-3β translocates to mitochondria, promoting mPTP openi...

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Autores principales: Tanno, Masaya, Kuno, Atsushi, Ishikawa, Satoko, Miki, Takayuki, Kouzu, Hidemichi, Yano, Toshiyuki, Murase, Hiromichi, Tobisawa, Toshiyuki, Ogasawara, Makoto, Horio, Yoshiyuki, Miura, Tetsuji
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200279/
https://ncbi.nlm.nih.gov/pubmed/25187518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.563924
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