Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats

BACKGROUND: Type 2 diabetes mellitus (T2DM) worsens the outcome after myocardial infarction (MI). Here, we hypothesized that inhibition of dipeptidyl peptidase-4 (DPP-4) improves survival after MI in T2DM by modifying autophagy in the non-infarcted region of the heart. METHODS AND RESULTS: Under bas...

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Detalhes bibliográficos
Publicado no:Cardiovasc Diabetol
Main Authors: Murase, Hiromichi, Kuno, Atsushi, Miki, Takayuki, Tanno, Masaya, Yano, Toshiyuki, Kouzu, Hidemichi, Ishikawa, Satoko, Tobisawa, Toshiyuki, Ogasawara, Makoto, Nishizawa, Keitaro, Miura, Tetsuji
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531441/
https://ncbi.nlm.nih.gov/pubmed/26259714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-015-0264-6
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