Mechanisms of Mitochondrial Holocytochrome c Synthase and the Key Roles Played by Cysteines and Histidine of the Heme Attachment Site, Cys-XX-Cys-His

Mitochondrial cytochrome c assembly requires the covalent attachment of heme by thioether bonds between heme vinyl groups and a conserved CXXCH motif of cytochrome c/c(1). The enzyme holocytochrome c synthase (HCCS) binds heme and apocytochrome c substrate to catalyze this attachment, subsequently r...

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Detalhes bibliográficos
Main Authors: Babbitt, Shalon E., San Francisco, Brian, Mendez, Deanna L., Lukat-Rodgers, Gudrun S., Rodgers, Kenton R., Bretsnyder, Eric C., Kranz, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200240/
https://ncbi.nlm.nih.gov/pubmed/25170082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593509
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